New Codes – and a Refresher 

According to ICD-10, gone are the days when you had to be chemically dependent on a substance in order to experience withdrawal (I will defer my criticism of that logic to another time): 

  • F10 Alcohol abuse with withdrawal series
  • F11 Opioid abuse with withdrawal series
  • F13 Sedative, anxiety, or hypnotic abuse
  • F14 Cocaine abuse with withdrawal series 

There is even F19, “other psychoactive” abuse with withdrawal series.

Given the codes above, obviously not everyone who is confused or experiencing delirium has perceptual disturbances, etc. related to a substance. A patient may have “toxic encephalopathy,” no matter what some of the consultants may tell you. Logic would dictate that at least sometimes, these CC level substance codes are more appropriate.

When would these codes be more appropriate? When the symptoms are directly related to these specific neuro-active substances, and when the symptoms are somewhat expected as known effects of such medications (or the withdrawal of same).

When the reaction is not just an adverse effect or part of withdrawal situation, or the dosages/blood levels/tox screens were extremely high and symptoms were well above or worse than what routinely be seen, then you may begin to build your clinical rationale for moving to toxic encephalopathy. If you do so, the expectation is that the resource utilization of the facility would be at a level much higher than that of the routine care normally provided for mild withdrawal, or adverse reactions of prescription opioids/sedatives/anxiety meds. Look for a transfer to a higher level of care, more frequent neuro checks, intensive respiratory and vital checks, a sitter, heavy sedation, possibly airway protection, restraints, a protracted (48 hours or more) period of extreme confusion, possibly violent/aggressive behavior, and some context that this is not just care for a routine detox or adverse reaction, somewhere in the physician’s documentation.

Quickly resolving episodes of confusion in response to neuro-active medications is probably better identified as the drug-induced delirium due to known physiological cause (F05) category. Oddly enough, delirium of unknown etiology indexes to R41.0 “Disorientation” (a non-CC), while simply having “acute confusional state” will index to F05 (a CC). We know what some auditors will do with that; suddenly, all unspecified delirium is cured, and everyone in the U.S. is in an acute confusional state!

If, however, the substance is not a neuro-active drug (such as an antibiotic) and the reaction is somewhat atypical, Coding Clinic does allow a move towards toxic encephalopathy (even if it is labeled as an adverse reaction).

As always, this is complicated. If the encephalopathy is attributed to a disease process, but not a metabolic or toxic issue specifically, it will be reported as “other” (G93.40), and septic is G93.41 (metabolic).

Somehow, diabetic hypoglycemia (according to Coding Clinic) can still be reported as metabolic encephalopathy (I personally don’t recommend doing this if it was rapidly resolved with standing orders, with no additional workup or lasting impacts, but that is opinion, not guidance), while a patient with hepatic encephalopathy is still only reported as having cirrhosis (tell me which of those two requires more hospital resource utilization to fix!)

Facebook
Twitter
LinkedIn

Allen Frady, RN, CCDS, CCS

Allen Frady, RN has been in the healthcare industry for over 25 years. He is currently working with 3M as a solutions advisor and specializes in CDI and coding. He is known as an instructor, author, website creator, and podcaster.

Related Stories

CMS POSTS 80 New PCS Codes

CMS Posts 80 New PCS Codes

With the April 1 update, the Centers for Medicare and Medicaid Services (CMS) implemented 80 new PCS codes. To break it down, there are 24

Read More

Leave a Reply

Please log in to your account to comment on this article.

Featured Webcasts

Mastering Breast Biopsy Billing: Guidance-Driven Coding for Accurate Reimbursement

Breast biopsy procedures may be clinically straightforward but accurately translating them into compliant billing can be anything but. In this focused webcast, Shawn Blackburn, CPC, CPMA, CIC, CRC, CCS-P breaks down how imaging guidance, lesion count, laterality, and payer expectations all impact how these procedures should be reported. Through clear explanations and real-world scenarios, you’ll gain practical insight into aligning clinical workflows with billing requirements, avoiding common pitfalls, and ensuring your documentation supports accurate reimbursement and compliance.

May 21, 2026

Mastering OB GYN Coding Accuracy: Precision Coding for Compliance and Reimbursement

Gain clarity and confidence in OB‑GYN coding with this expert‑led webcast featuring Sherri L. Clayton, RHIT, CSS. You’ll learn how to apply global maternity package rules accurately, select the right CPT codes for procedures and visits, and identify documentation gaps that lead to denials. With practical guidance and real examples, this session helps you strengthen compliance, reduce audit risk, and ensure accurate reimbursement for women’s health services.

May 14, 2026

2026 ICD-10-CM/PCS Coding Clinic Update Webcast Series

Uncover essential coding insights with nationally recognized coding authority Kay Piper, RHIA, CDIP, CCS. Through ICD10monitor’s interactive, on‑demand webcast series, Kay walks you through the AHA’s 2026 ICD‑10‑CM/PCS Quarterly Coding Clinics, translating each update into practical, easy‑to‑apply guidance designed to sharpen precision, ensure compliance, and strengthen day‑to‑day decision‑making. Available shortly after each official release.

April 13, 2026

2026 ICD-10-CM/PCS Coding Clinic Update: Fourth Quarter

Uncover critical guidance on the ICD-10-CM/PCS code updates. Kay Piper reviews and explains ICD-10-CM/PCS coding guidelines in the AHA’s fourth quarter 2026 ICD-10-CM/PCS Coding Clinic in an easy to access on-demand webcast.

December 14, 2026

Trending News

Featured Webcasts

Reengineering Utilization Management: Building an Adaptive Model for the New Payer Era

Traditional utilization management models can no longer keep pace with regulatory shifts, payer scrutiny, and operational pressures. In this webcast, Tiffany Ferguson, LMSW, CMAC, ACM, ACPA-C, introduces an Adaptive Model strategy that modernizes UM through role specialization, technology-driven workflows, and proactive, team-based processes. Attendees will learn how to restructure programs to improve efficiency, strengthen clinical collaboration, and enhance financial performance in a rapidly changing healthcare environment.

May 20, 2026

Compliance for the Inpatient Psychiatric Facility (IPF-PPS): Minimizing Federal Audit Findings by Strengthening Best Practices

Federal auditors are intensifying their focus on inpatient psychiatric facilities, using advanced data analytics to spotlight outliers and pursue high‑dollar repayments. In this high‑impact webcast, Michael Calahan, PA, MBA, Compliance Officer and V.P., Hospital & Physician Compliance, breaks down what regulators are really targeting in IPF-PPS admissions, documentation, treatment and discharge planning. Attendees will learn practical steps to tighten processes, avoid common audit triggers and protect reimbursement and reduce the risk of multimillion-dollar repayment demands.

April 9, 2026

Mastering MDM for Accurate Professional Fee Coding

In this timely session, Stacey Shillito, CDIP, CPMA, CCS, CCS-P, CPEDC, COPC, breaks down the complexities of Medical Decision Making (MDM) documentation so providers can confidently capture the true complexity of their care. Attendees will learn practical, efficient strategies to ensure documentation aligns with current E/M guidelines, supports accurate coding, and reduces audit risk, all without adding to charting time.

March 31, 2026

The PEPPER Returns – Risk and Opportunity at Your Fingertips

Join Ronald Hirsch, MD, FACP, CHCQM for The PEPPER Returns – Risk and Opportunity at Your Fingertips, a practical webcast that demystifies the PEPPER and shows you how to turn complex claims data into actionable insights. Dr. Hirsch will explain how to interpret key measures, identify compliance risks, uncover missed revenue opportunities, and understand new updates in the PEPPER, all to help your organization stay ahead of audits and use this powerful data proactively.

March 19, 2026

Trending News

Happy HIP Week! Sign up to win free access to our 2026 Coding Clinic Update Webcast Series! Click here to learn more →

Prepare for the 2025 CMS IPPS Final Rule with ICD10monitor’s IPPSPalooza! Click HERE to learn more

Get 15% OFF on all educational webcasts at ICD10monitor with code JULYFOURTH24 until July 4, 2024—start learning today!

CYBER WEEK IS HERE! Don’t miss your chance to get 20% off now until Dec. 1 with code CYBER25

CYBER WEEK IS HERE! Don’t miss your chance to get 20% off now until Dec. 2 with code CYBER24